From Los Angeles use 1-5 South to La Jolla Village Drive, then west to Torrey Pines Road.  From Torrey Pines Road turn right onto Prospect, then left onto Fay Ave. to the Best Western Inn by the Sea.
 

From San Diego, use 1-5 North to La Jolla Parkway (formally Ardath Road), then proceed west to Torrey pines Road.  From Torrey Pines Road turn right onto Prospect, then left onto Fay Ave. to the Best Western Inn by the Sea.